Wednesday, September 18, 2013

Statins review paper

.
"Nuclear explosion" is probably a better term than review!

Source Wiki


"The Ugly Side of Statins. Systemic Appraisal of the Contemporary Un-Known Unknowns" by Sherif Sultan and Niamh Hynes published in Open Journal of Endocrine and Metabolic Diseases, 2013, 3, 179-185.

The whole text is well worth reading in its entirety! Some quotations:

From the Abstract:

A comprehensive review of Pubmed, EM-BASE and Cochrane review databases was undertaken for articles relating to cardiovascular primary prevention and statin side effects with the aim of harmonising their roles within contemporary clinic practice. Particular attention was paid to large-scale randomised controlled trials on contemporary cardiovascular pharmacotherapies and their specific adverse effects on metabolic pathways which feature prominently in cardiovascular primary prevention and regenerative programmes.

There is a categorical lack of clinical evidence to support the use of statin therapy in primary prevention. Not only is there a dearth of evidence for primary cardiovascular protection, there is ample evidence to show that statins actually augment cardiovascular risk in women, patients with Diabetes Mellitus and in the young. Furthermore statins are associated with triple the risk of coronary artery and aortic artery calcification.
...
Utmost Medical Tragedy.

We seem to have fallen into the marketing trap and ignored the niggling side effects with regard to the HMG-CoA reductase inhibitors [1]. The only statin benefit that has actually been demonstrated is in middle aged men with coronary heart disease. However, statins were not shown to best form of primary prevention. Aspirin, as a form of primary prevention decreases the risk for total cardiovascular events and nonfatal Myocardial Infarction over any other factor [5]. In actual fact, high cholesterol levels have been found to be protective in elderly and heart failure patients and hypo-cholestereamic patients had higher incidence of intra-cerebral bleeds, depression and cancer [1].

The statin industry, with all of its spin-off, is a 20-billion-a-year industry. We are observing the revealing of the utmost medical tragedy of all times. It is unprecedented that the healthcare industry has inadvertently induced life-threatening nutrient deficiency in millions of otherwise healthy people. What is even more disparaging is that not only has there been a failure to report on these negative side-effects of statins, there has actually been active discouragement to publish any negative studies on statins.

Statins induce diabetes.


The US Veterans affair healthcare system study on 15 million veterans in 10 hospitals in Southern USA concluded that statins affect fasting and postprandial glucose level by inducing a state of hyperglycaemia in diabetic as well as non diabetic patients [12]. This relationship between statin use and rise in glucose level is independent of age and use of aspirin, beta blockers and angiotensin-converting enzyme inhibitors. Furthermore, a sub-analysis of the JUPITER study showed that statin therapy can induce full blown type 2 diabetes in women [13]. This was astonishingly shown in the sub study of PRO-VE-IT TIMI 22, in which there was a significant increased risk of developing HBA1c > 6% in both diabetics and non diabetics [14]. Moreover Huptas et al. have demonstrated that statin therapy can induce a state of insulin resistance [15].
...
Statins manipulate glucose metabolism as a consequence of inhibitory effects on adipocytes. They induce insulin resistance through reduction in insulin-stimulated glucose uptake with a strong impact on glycaemic control in non obese patients.
...
Preiss et al. [19] demonstrated, in a pooled analysis of data from the five major statin trials, an increased incidence of new onset diabetes with statin therapy and provided evidence of a dose dependent association.

Statins accelerate arterial calcification.

The Confirm registry had shocked the scientific world with the strongest evidence that statin use is associated with an increased prevalence and extent of coronary plaques calcification [32]. Ironically for a drug which was marketed to lower the risk of cardiovascular disease, the confirm registry identified a strong association of statin use to the progression of coronary artery plaque features. Moreover, Statin use was correlated with a greater incidence of severe coronary artery stenosis as well as increase in the numbers of coronary vessels developing obstructive coronary artery disease. Furthermore, statin use was linked to an increase in the prevalence and extent of mixed calcific plaque. Five prospective studies have borne witness to the fact that statin therapy does not induce any coronary calcium regression and evolution of coronary calcium continues regardless of statin treatment[33,34]. The Veteran Affairs Diabetes Trial [35] established that statin consumption was linked to accelerated progression of Coronary Artery Calcification (CAC) in participants with Type 2 Diabetes Mellitus without previous coronary artery disease, despite the fact that statin users had significantly lower and nearly optimal LDL-cholesterol levels.

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Updated 5-Oct-2013, press news by Irish Independent:

"HSE gags surgeon after cholesterol drug claims"

A LEADING vascular surgeon [Sherif Sultan], whose research review concluded cholesterol-lowering medicines may do more harm than good for many otherwise healthy people, has been gagged by the Health Service Executive. ...



6 comments:

Richard said...

Excellent paper Stan, seems aptly timed, what with the Statin Class recently coming off patent and the race to bring out the PCSK9 Inhibitors by the usual players.

http://www.ncbi.nlm.nih.gov/pubmed/23817198

Would be good to see a full text of the above link.

Stan (Heretic) said...

Scary! BTW I am wondering if these authors sign their real names, since they are exposing themselves to future class action lawsuits! A standard "Nuremberg" defence line of "following the official orders" that may be working for ordinary physicians, could be potentially challenged in case of prominent opinion-making scientists who are in the position of power or actively help the authorities and drug corporations implementing theor harmful policies. They cannot claim now that they did not know what harm may have resulted from their actions! Witness the recent sentencing of a a few Italian scientists for -bullshitting- the public before and during the recent earthquake in Italy, a few years ago. It was a very good and long sought-after precedent! I hope more will come.

[rant=on]

For thousands of years, various ideologues and intellectuals used to walk in the air of infallibility and immunity, believing that no amount of bullshit and manipulation may land them in jail, even though some of the belief systems they have created and implemented became some of the most powerful weapons of mass destructions obliterating the entire civilisations, cultures and lives!

dav0 said...

dgmsent 7bUnsurprisingly, this happened: http://www.independent.ie/irish-news/hse-gags-surgeon-after-cholesterol-drug-claims-29636095.html

Sam said...

It probably won't be long before the lawyers latch onto this. Billions. I had a class on legal aspects of business and the lawyer/teacher that taught it was probably one of the most cynical people I'm ever met. He was also however very much a rational take things as they are kind of person also.

Richard said...

Is the tide turning..

http://www.bmj.com/content/347/bmj.f6340

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