.A new lead:
Feeling Cold May Add Years to Your Life
Living in cold and frigid temperatures may be worth while as new research shows possible benefits of cold air for humans. A research study done at the University of Michigan observed the effects of cold air on the gene receptor, TRPA-1. The TRPA-1 receptor channel can be found in the nerve and fat cells of nematodes, also known as roundworms. It was discovered that roundworms live significantly longer under colder environments because the cold air seems to start a domino effect beginning with the receptor that eventually leads to the activation of the DAF-16/FOXO, the gene linked to longevity.
Due to this new research, the human body's receptors should ideally trigger the longevity gene when it comes into contact with cold air. The research also concluded that mice, which are also warm blooded mammals, can live longer when their body temperatures are lowered by 0.9 degrees Fahrenheit. It was measured that their lifespan can be lengthened by 20%. Warm blooded mammals can reduce their core body temperature by careful calories restrictions. However, these methods have not been practiced or studied with the human body. In addition to cold air, research shows that other factors, such as wasabi and mustard oil also act as triggers to this chain reaction.
Does ketogenic diet come in only as the pretext to consume wasabi and mustard? Not only, ketogenic diet stimulates production of methylglyoxal ["Methylglyoxal on Atkins... Uh oh!" , "Ketosis leads to increased methylglyoxal production on the Atkins diet."] which activates TRPA-1 [see "METHYLGLYOXAL ACTIVATES NOCICEPTORS THROUGH TRPA1..."]. Incidentally methylglyoxal also disrupts cancerous cells ["A brief critical overview of the biological effects of methylglyoxal..."]
More reading on the subject, and on Dr. Jack Kruse's Cold Thermogenesis ideas can be found in his blog.